Submitted by bandana on Tue, 2012-03-27 22:47
TitleUpregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors
Publication TypeJournal Article
Year of Publication2012
AuthorsNiinuma, Takeshi, Suzuki Hiromu, Nojima Masanori, Nosho Katsuhiko, Yamamoto Hiroyuki, Takamaru Hiroyuki, Yamamoto Eiichiro, Maruyama Reo, Nobuoka Takayuki, Miyazaki Yasuaki, Nishida Toshirou, Bamba Takeo, Kanda Tatsuo, Ajioka Yoichi, Taguchi Takahiro, Okahara Satoshi, Takahashi Hiroaki, Nishida Yasunori, Hosokawa Masao, Hasegawa Tadashi, Tokino Takashi, Hirata Koichi, Imai Kohzoh, Toyota Minoru, and Shinomura Yasuhisa
JournalCancer Research
Date PublishedJanuary 18
KeywordsmiRNA
URLhttp://cancerres.aacrjournals.org/content/72/5/1126.short
Notes

Technology: Human miRNA Microarray V3 (Agilent), RT-PCR (Applied Biosystems), Whole Human Genome Oligo DNA microarray (Agilent), Comparative genome hybridization (CGH)
Research Focus: Evaluate the contribution made by miRNAs to the malignant potential of gastrointestinal stromal tumors and to identify predictive biomarkers. The study aimed to determine the upregulation of miR-196a which is strongly associated with high risk and poor prognosis in GIST patients. Also, the study provided evidence that overexpression of miR-196a is accompanied by upregulation of HOXC cluster genes and metastasis-associated noncoding RNA in GISTs.