From GeneSpring 12.0 onwards, Single Experiment Analysis (SEA) replaces the Find Significant Pathways (FSP) workflow step available in earlier versions. Compared to FSP, SEA is enhanced with some of the features that were introduced to enable Multi-Omic Analysis (MOA). SEA identifies matching pathways for the entities of one experiment, compared to two experiments in an MOA. But unlike in the previous FSP workflow, you can now choose a differing organism for pathway analysis from the organism associated with your chosen experiment and specify an experiment interpretation as well as preferred annotations. In addition, the new curated pathways options (WikiPathways and pathways in .gpml format) as well as the BioPAX, Hand created, NLP and MeSH options can also be selected as pathway sources for pathway analysis.