Every time you update an Interaction Database in GeneSpring, the Update Pathways dialog opens automatically. This dialog allows you to choose which of the pathways that you previously imported into GeneSpring (non-GPML format only) you would like to update or delete based on the new information recorded in the updated Interaction Database. For each pathway the Update Pathways dialog displays updated entities and obsolete entities. If you want to update pathways at a later date, you can return to the Update Pathways dialog through Annotations > Update Pathways.