Steps: Open GeneSpring> Go to Tools menu> Import Pathways from BioCyc> From Update File> Choose the .Update file downloaded from here (Only available from GeneSpring 12.5 onwards).

BioCyc Pathways for GeneSpring 12.5 onwards

Organism	Biocyc Pathway
Human	BioCyc Pathway
Mouse	BioCyc Pathway
Yeast	BioCyc Pathway

Steps: Open GeneSpring> Go to Annotations menu> Update BridgeDb> From Update File> Choose the .Update file downloaded from here.

Bridge DBs for GeneSpring 12.0/12.1

The following Bridge DBs should be used only in GeneSpring 12.0/12.1

Organism	Bridge DB
Human	Bridge DB
Mouse	Bridge DB
Rat	Bridge DB

Bridge DBs for GeneSpring 12.5/12.6/12.6.1/13.0

The following Bridge DBs should be used only in GeneSpring 12.5/12.6/12.6.1/13.0

Organism	Bridge DB
Human	Bridge DB
Mouse	Bridge DB
Rat	Bridge DB

Steps: Open GeneSpring> Go to Annotations menu> Update Pathway Interactions> From Update File> Choose the .Update file downloaded from here.

Please contact us if you need annotations for organisms not listed above.

Human

Organism	Build	Annotations
Human	hg19 (build)	Conservation Genes & Transcripts Cytoband dbSNP131 dbSNP132 dbSNP135 dbSNP137 dbSNP138 Reference SmallRNA HAIB Genotype HAIB Methyl 450 HAIB Methyl RRBS DNase Clusters CpG Islands Gencode Genes SureSelect Targets microRNAorg Targets PITA (miRNA Targets) PicTar (miRNA Targets) TarBase (miRNA Targets) TargetScan (miRNA Targets)
	hg18 (build)	Conservation Genes & Transcripts Cytoband dbSNP130 Reference SmallRNA microRNAorg (miRNA Targets) PicTar (miRNA Targets) PITA (miRNA Targets) TarBase (miRNA Targets) TargetScan (miRNA Targets)
	Homology	Homology

Mouse

Organism	Build	Annotations
Mouse	mm8 (build)	Genes & Transcripts dbSNP Reference
	mm9 (build)	Genes & Transcripts dbSNP Reference SureSelect Targets microRNAorg (miRNA Targets) PicTar (miRNA Targets) PITA (miRNA Targets) TargetScan (miRNA Targets)
	mm10 (build)	Genes & Transcripts Reference
	Homology	Homology

Rat

Organism	Build	Annotations
Rat	rn4 (build)	Genes & Transcripts dbSNP Reference Conservation microRNAorg (miRNA Targets) TargetScan (miRNA Targets)
	rn5 (build)	Genes & Transcripts Reference
	Homology	Homology

Steps: Open GeneSpring> Go to Annotations menu> Update Pathway Interactions> From Update File> Choose the .Update file downloaded from here.

Interaction DBs for GeneSpring 12.0/12.1

The following Interaction DBs should be used only in GeneSpring 12.0/12.1.

Organism	Interaction database
Generic	Pathway Interaction Database
Human	Pathway Interaction Database
Mouse	Pathway Interaction Database
Rat	Pathway Interaction Database

Interaction DBs for GeneSpring 12.5/12.6/12.6.1/13.0

The following Interaction DBs should be used only in GeneSpring 12.5/12.6/12.6.1/13.0

Organism	Interaction database
Generic	Pathway Interaction Database
Homo sapiens	Pathway Interaction Database
Mus musculus	Pathway Interaction Database
Rattus norvegicus	Pathway Interaction Database
Arabidopsis thaliana	Pathway Interaction Database
Bacillus subtilis	Pathway Interaction Database
Caenorhabditis elegans	Pathway Interaction Database
Chlamydomonas reinhardtii	Pathway Interaction Database
Drosophila melanogaster	Pathway Interaction Database
Escherichia coli	Pathway Interaction Database
Mycobacterium tuberculosis	Pathway Interaction Database
Neurospora crassa	Pathway Interaction Database
Oryza sativa	Pathway Interaction Database
Plasmodium falciparum	Pathway Interaction Database
Saccharomyces cerevisiae	Pathway Interaction Database
Zea mays	Pathway Interaction Database

If you are unable to download the Technologies, Annotations, Bridge DB and Pathway Interaction databases directly from the server via Annotations menu in the tool, then you could use the links below to download the file based updates.

Agilent Technologies

Steps: Open GeneSpring> Go to Annotations menu> Create Technology> From GeneSpring Update File> Choose the .Update file downloaded from here.

Organism	Technology
Agilent Single Color Human	Human 11871 Human_11521 Human_12097 Human_12391 Human_14850 Human_15034 Human_26652 Human_28004 Human_28679 Human_72363
Agilent Single Color Mouse	Mouse_11472 Mouse_11978 Mouse_12694 Mouse_12799 Mouse_13326 Mouse_14868 Mouse_15062 Mouse_26655 Mouse_28005 Mouse_74809
Agilent Single Color Rat	Rat_11868 Rat_13162 Rat_14879 Rat_28279 Rat_28282 Rat_74036
Agilent Two Color Human	Human 11871 Human_11521 Human_12097 Human_12391 Human_14850 Human_15034 Human_26652 Human_28004 Human_28679
Agilent Two Color Mouse	Mouse_11472 Mouse_11978 Mouse_12694 Mouse_12799 Mouse_13326 Mouse_14868 Mouse_15062 Mouse_26655 Mouse_28005
Agilent Two Color Rat	Rat_11868 Rat_13162 Rat_14879 Rat_28279 Rat_28282
Agilent miRNA Human	Human_70156_v21_0 Human_16436_v19_0 Human_16436_v18_0 Human_16436_v17_0 Human_16436_v15_0 Human_16436_v13_0 Human_16436_v12_0 Human_16436_v9_1 Human_19118_v19_0 Human_19118_v18_0 Human_19118_v17_0 Human_19118_v15_0 Human_19118_v14_0 Human_19118_v13_0 Human_19118_v10_0 Human_21827_v19_0 Human_21827_v18_0 Human_21827_v17_0 Human_21827_v15_0 Human_21827_v14_0 Human_21827_v13_0 Human_21827_v12_0 Human_29297_v19_0 Human_29297_v18_0 Human_29297_v17_0 Human_29297_v15_0 Human_31181_v18_0 Human_31181_v17_0 Human_31181_v16_0 Human_41686_v18_0
Agilent miRNA Mouse	Mouse_70155_v21_0 Mouse_19119_v19_0 Mouse_19119_v18_0 Mouse_19119_v17_0 Mouse_19119_v15_0 Mouse_19119_v14_0 Mouse_19119_v10_1 Mouse_29298_v19_0 Mouse_29298_v18_0 Mouse_29298_v18_0 Mouse_29298_v18_0 Mouse_21828_v19_0 Mouse_21828_v18_0 Mouse_21828_v17_0 Mouse_21828_v15_0 Mouse_21828_v14_0 Mouse_21828_v10_1 Mouse_31184_v19_0 Mouse_31184_v18_0 Mouse_31184_v17_0 Mouse_31184_v16_0 Mouse_29152_v19_0 Mouse_29152_v18_0 Mouse_29152_v17_0 Mouse_29152_v15_0 Mouse_38112_v19_0 Mouse_38112_v18_0
Agilent miRNA Rat	Rat_70154_v21_0 Rat_19159_v19_0 Rat_19159_v18_0 Rat_19159_v17_0 Rat_19159_v15_0 Rat_19159_v13_0 Rat_19159_v12_0 Rat_19159_v10_1 Rat_31189_v19_0 Rat_31189_v18_0 Rat_31189_v17_0 Rat_31189_v16_0 Rat_29200_v19_0 Rat_29200_v18_0 Rat_29200_v17_0

Affymetrix Technologies

Steps: Open GeneSpring> Go to Annotations menu> Create Technology> From GeneSpring Update File> Choose the .Update file downloaded from here.

Organism	Technology
Affymetrix Geno Chip Human	Genomewide_SNP5 Genomewide_SNP6 Mapping 250K_Hind240 Mapping 250K_Nsp Mapping50K_Hind240__Mapping50K_Xba240 Mapping50K_xba240 Mapping250k_Nsp__Mapping250k_sty Mapping250K_Sty
Affymetrix Gene Chip Human	HC_G110 HG-Focus HG-U133A HG-U133A_2 HG-U133_Plus_2 HG-U219 HG_U95A HG_U95Av2 HG_U95B HG_U95C HG_U95D HG_U95E HT_HG-U133_Plus_PM
Affymetrix Gene Chip Mouse	Medicago MG_U74Av2 MG_U74Bv2 MG_U74Cv2 MOE430A MOE430B Mouse430_2
Affymetrix Gene Chip Rat	RAE230A RAE230B
Affymetrix Exon Chip Human	HuEx-1_0-st-v2 HuEx-1_0-st-v2_na33_1_hg19_2012-12-10 HuEx-1_0-st-v2_na30_hg19_2009-11-09 HuEx-1_0-st-v2_na31_hg19_2010-08-27 HuEx-1_0-st-v2_na32_hg19_2011-06-23 HuGene-1_0-st-v1_na30_1_hg19_2010-01-22 HuGene-1_0-st-v1_na31_hg19_2010-09-03 HuGene-1_0-st-v1_na32_hg19_2011-09-30 HuGene-1_0-st-v1 HuGene-1_1-st-v1_na30_1_hg19_2010-01-22 HuGene-1_1-st-v1_na31_hg19_2010-09-03 HuGene-1_1-st-v1_na32_hg19_2011-09-30 HuGene-2_0-st_na34_hg19 HuGene-2_1-st_na34_hg19
Affymetrix Exon Chip Mouse	MoEx-1_0-st-v1 MoEx-1_0-st-v1_na30_mm9_2009-11-09 MoEx-1_0-st-v1_na32_mm9_2011-06-23 MoGene-1_0-st-v1_na30_1_mm9_2009-12-08 MoGene-1_0-st-v1_na31_mm9_2010-08-27 MoGene-1_0-st-v1_na32_mm9_2011-10-07 MoGene-1_1-st-v1_na30_1_mm9_2009-12-08 MoGene-1_1-st-v1_na31_mm9_2010-08-27 MoGene-1_1-st-v1_na32_mm9_2011-10-13 MoGene-2_0-st_na34_mm10 MoGene-2_1-st_na34_mm10
Affymetrix Exon Chip Rat	RaEx-1_0-st-v1 RaEx-1_0-st-v1_na30_rn4_2009-11-09 RaEx-1_0-st-v1_na31_rn4_2010-08-27 RaEx-1_0-st-v1_na32_rn4_2011-06-23 RaGene-1_0-st-v1 RaGene-1_0-st-v1_na31_rn4_2010-08-27 RaGene-1_0-st-v1_na32_rn4_2011-06-23 RaGene-1_1-st-v1_na30_1_rn4_2009-12-08 RaGene-1_1-st-v1_na32_rn4_2011-06-23 RaGene-2_0-st_na34_rn5 RaGene-2_1-st_na34_rn5

Illumina Technologies

Steps: Open GeneSpring> Go to Annotations menu> Create Technology> From GeneSpring Update File> Choose the .Update file downloaded from here.

Organism	Technology
Illumina Human	HumanHT-12_V3_0_R1_11283641_A HumanHT-12_V3_0_R2_11283641_A HumanHT-12_V3_0_R3_11283641_A HumanHT-12_V4_0_R1_15002873_B HumanHT-12_V4_0_R2_15002873_B HumanHT-12_V4_0_R2_15002873_B_WGDASL HumanRef-8_V2_0_R0_11223162_A HumanRef-8_V2_0_R1_11223162_A HumanRef-8_V2_0_R2_11223162_A HumanRef-8_V2_0_R3_11223162_A HumanRef-8_V2_0_R4_11223162_A HumanRef-8_V3_0_R0_11282963_A
Illumina Mouse	MouseRef-8_V1_1_R0_11234312_A MouseRef-8_V1_1_R1_11234312_A MouseRef-8_V1_1_R2_11234312_A MouseRef-8_V1_1_R3_11234312_A MouseRef-8_V1_1_R4_11234312_A MouseRef-8_V2_0_R0_11278551_A MouseRef-8_V2_0_R1_11278551_A MouseRef-8_V2_0_R2_11278551_A MouseRef-8_V2_0_R3_11278551_A MouseWG-6_V1_1_R0_11234304_A MouseWG-6_V1_1_R1_11234304_A MouseWG-6_V1_1_R2_11234304_A MouseWG-6_V1_1_R3_11234304_A MouseWG-6_V1_1_R4_11234304_A MouseWG-6_V2_0_R0_11278593_A MouseWG-6_V2_0_R1_11278593_A MouseWG-6_V2_0_R2_11278593_A MouseWG-6_V2_0_R3_11278593_A
Illumina Rat	RatRef-12_V1_0_R0_11222119_A RatRef-12_V1_0_R1_11222119_A RatRef-12_V1_0_R2_11222119_A Ratref-12_V1_0_R3_11222119_A RatRef-12_V1_0_R4_11222119_A RatRef-12_V1_0_R5_11222119_A

BioCyc Pathways

BioCyc Pathways for GeneSpring 12.5 onwards

Bridge Databases

Bridge DBs for GeneSpring 12.0/12.1

Bridge DBs for GeneSpring 12.5/12.6/12.6.1/13.0

NGS Annotations

Human

Mouse

Rat

Pathway Interaction Databases

Interaction DBs for GeneSpring 12.0/12.1

Interaction DBs for GeneSpring 12.5/12.6/12.6.1/13.0

Technology

Agilent Technologies

Mouse

Rat

Agilent Two Color Mouse

Affymetrix Technologies

Illumina Technologies

Resources