For version 12.5, the database management system for storing GeneSpring data (e.g. experiments, analysis results, annotations, pathway-related databases) was changed from MySQL to PostgreSQL. Therefore, all the existing data has to be migrated from the MySQL database to the PostgreSQL database before you can start working with GeneSpring again. Depending on the size of your data (for example if you have previously downloaded interaction databases of multiple organisms), this process can take several hours.