A. GeneSpring supports Affymetrix CEL and CHP files as standard format.
The other file formats such as .txt, .xls, .tsv and .csv are not recognised a standard file formats from affymetrix, but can be imported into GeneSpring for analysis.
You could work with .xls file by ‘Creating a Custom Technology’. To create a custom technology, follow the steps below:
1. Go to Annotations in the Menu bar -> Create Technology -> Custom from File
2. After creating the custom technology, you could create the experiment under ‘Generic Single color’ Experiment Type.
For more details please refer Chapter 13 & 14 on ‘Analyzing Generic Single color/Two Color Expression Data’ from the GeneSpring Manual.