It is recommended to consult GeneSpring Support (informatics_support [at] agilent [dot] com) before OS upgrade.
Backup and Restore will solve this issue. However, since there is no original filesystem to go back after your OS is upgraded, we strongly recommend to also perform the following:
a) Export important individual projects.
b) Keep a copy of the following:
           i) "app" folder from GeneSpring installation directory.
           ii) All previous repository data folders, if any.