GeneSpring supports the import of pathways from the WikiPathways portal (directly in GeneSpring or as GPML files that were previously downloaded from the portal, also see Q1. How can I import pathways from WikiPathways in GeneSpring?). You can also import pathways from BioCyc directly in GeneSpring (see Q2. How can I import pathways from BioCyc in GeneSpring?). In addition, you can import pathway files in the BioPAX (Level 2 and Level 3, *.owl) , GPML (*.gpml), and Text (*.txt) format.