It really depends on what kind of samples you are working with. Please find the benchmarking table for GeneSpring version in the table below:

Experiment Type No.of samples Memory used for experiment creation Run time memory Technology type
Agilent Single Color(Sample type-22K) 500 200M 300M 12097
Affymetrix Exon Splicing(RMA-Full) 50 583M 1009M HuEx-1_0-st-V2
Affymetrix Exon Splicing(PLIER-Full) 50 570M 1009M HuEx-1_0-st-V2
Affymetrix Exon Expression(RMA-Full) 50 187M 3589M HuEx-1_0-st-V2
Affymetrix Exon Expression(PLIER-Full) 50 187M 3589M HuEx-1_0-st-V2
Affymetrix Expression(RMA) 51 36M 64M HG_U95Aw2
Affymetrix Expression(PLIER) 52 34M 56M HG_U95Aw2

Note: Benchmarking for copy number and Association analysis are not included here.